Publications

Selected publications:

  • Lerche M, Elosegui-Artola A, Guzman C, Kechagia J, GeorgiadouM, GullbergD, Roca-Cusachs P, Peuhu E, and Ivaska J (2020): Integrin binding dynamics modulate ligand-specific mechanosensing in mammary gland fibroblasts. iScience. https://doi.org/10.1016/j.isci.2020.100907
  • Isomursu A, Lerche M, Taskinen ME, Ivaska J & Peuhu E (2019): Integrin signaling and mechanotransduction in regulation of somatic stem cells. Experimental Cell Research. 378: 217-225
  • Peuhu E, Virtakoivu R, Mai A, Wärri A, and Ivaska J (2017): Epithelial vimentin plays a functional role in mammary gland development. Development 144:4103-4113.
  • Peuhu E, Kaukonen R, Lerche M, Saari M, Guzmán C, Rantakari P, De Franceschi N, Wärri A, Georgiadou M, Jacquemet G, Mattila E, Virtakoivu R, Liu Y, Attieh Y, Silva KA, Betz T, Sundberg JP, Salmi M, Deugnier M-A, Eliceiri KW, and Ivaska J (2017): SHARPIN regulates collagen architecture and ductal outgrowth in the developing mouse mammary gland. The EMBO Journal 36, 165-182.

All publications:

Lerche M, Elosegui-Artola A, Guzman C, Kechagia J, GeorgiadouM, GullbergD, Roca-Cusachs P, Peuhu E, and Ivaska J (2020): Integrin binding dynamics modulate ligand-specific mechanosensing in mammary gland fibroblasts. iScience. https://doi.org/10.1016/j.isci.2020.100907

Laukka M, Hoppela E, Salo J, Rantakari P, Grönroos TJ, Orte K, Auvinen K, Salmi M, Gerke H, Thol K, Peuhu E, Kauhanen S, Merilahti P, and Hartiala P (2019): Preperitoneal Fat Grafting Inhibits the Formation of Intra-abdominal Adhesions in Mice. Journal of Gastrointestinal Surgery. 2019 Dec 10. doi: 10.1007/s11605-019-04425-4.

Vafaizadeh V*, Peuhu E*, Mikkola ML, Khaled WT, Bentires-Alj M, and Koledova Z (2019): The Eleventh ENBDC Workshop: Advances in Technology Help to Unveil Mechanisms of Mammary Gland Development and Cancerogenesis. Journal of Mammary Gland Biology and Neoplasia. Sep;24(3):201-206.

Pietilä M, Sahgal P, Peuhu E, Jäntti N, Paatero I, Andersen OM, Padzik A, Blomqvist M, Taimen P, Boström P, Sihto H, Joensuu H, and Ivaska J (2019): SORLA regulates endosomal trafficking and oncogenic fitness of HER2. Nature Communications, 10: 2340.

Siitonen R, Peuhu E, Autio A, Liljenbäck H, Mattila E, Metsälä O, Käkelä M, Saanijoki T, Dijkgraaf I, Jalkanen S, Ivaska J & Roivainen A (2019): 68Ga-DOTA-E[c(RGDfK)]2 Positron Emission Tomography Imaging of SHARPIN-Mediated Integrin Activity in Mice. Journal of Nuclear Medicine, jnumed.118.222026. doi: 10.2967/jnumed.118.222026.

Isomursu A, Lerche M, Taskinen ME, Ivaska J & Peuhu E (2019): Integrin signaling and mechanotransduction in regulation of somatic stem cells. Experimental Cell Research. 378: 217-225.

Peuhu E*,#, Virtakoivu R*, Mai A, Wärri A, and Ivaska J (2017): Epithelial vimentin plays a functional role in mammary gland development. Development 144:4103-4113.

Peuhu E#, Salomaa S, De Franceschi N, Potter CS, Sundberg JP and Pouwels J (2017): Integrin beta1 inhibition alleviates the chronic hyperproliferative dermatitis phenotype of SHARPIN-deficient mice. PLoS ONE 12: e0186628.

Lilja J, Zacharchenko T, Georgiadou M, Jacquemet G, De Franceschi N, Peuhu E, Hamidi H, Pouwels J, Martens V, Hassani Nia F, Beifuss M, Boeckers T, Kreienkamp H-J, Barsukov IL & Ivaska J (2017): SHANK proteins limit integrin activation by directly interacting with Rap1 and R-Ras. Nature Cell Biology    19, 292–305.

Peuhu E#, Kaukonen R, Lerche M, Saari M, Guzmán C, Rantakari P, De Franceschi N, Wärri A, Georgiadou M, Jacquemet G, Mattila E, Virtakoivu R, Liu Y, Attieh Y, Silva KA, Betz T, Sundberg JP, Salmi M, Deugnier M-A, Eliceiri KW, and Ivaska J (2017): SHARPIN regulates collagen architecture and ductal outgrowth in the developing mouse mammary gland.The EMBO Journal 36, 165-182.

Kaur A, Denisova O, Qiao X, Jumppanen M, Peuhu E, Ahmed S, Raheem O, Haapasalo H, Eriksson J, Chalmers A, Laakkonen P, and Westermarck J (2016) PP2A inhibitor PME-1 drives kinase inhibitor resistance in glioma cells. Cancer Research 76:7001-7011.

Jacquemet G, Baghirov H, Georgiadou M, Sihto H, Peuhu E, Cettour-Janet P, He T, Perälä M, Kronqvist P, Joensuu H, and Ivaska J (2016): L-type calcium channels regulate filopodia stability and cancer cell invasion downstream of Integrin signaling. Nature communications. 7: 13297.

Rantakari P, Jäppinen N, Lokka E, Mokkala E, Gerke H, Peuhu E, Ivaska J, Elima K, Auvinen K, and Salmi M (2016): Fetal liver endothelium regulates the seeding of tissue-resident macrophages. Nature 538:392-396.

De Franceschi N, Peuhu E, Parsons M, Rissanen S, Vattulainen I, Salmi M,  Ivaska J, and Pouwels J (2015): Mutually Exclusive Roles of SHARPIN in Integrin Inactivation and NF-κB Signaling. PLoS One 10: e0143423.

Paul P, Kumar Rajendran S*, Peuhu E*, Alshatwi AA, Mohammad AA, Hietanen S, and Eriksson JE (2014): Novel action modality of the diterpenoid anisomelic acid causes depletion of E6 and E7 viral oncoproteins in HPV-transformed cervical carcinoma cells. Biochemical Pharmacology. 89:171–184.

Peuhu E, Paul P, Remes M, Holmbom T, Eklund P, Sjöholm R, and Eriksson JE (2013): The antitumor lignan Nortrachelogenin sensitizes prostate cancer cells to TRAIL-induced cell death by inhibition of the Akt pathway and growth factor signaling. Biochemical Pharmacology 86:571–583.

Mamaeva V,Rosenholm JM, Tabe Bate-Eya L,Bergman L, Peuhu E, Duchanoy A, Fortelius LE, Landor S,Toivola DM, Lindén M, and Sahlgren C(2011): Mesoporous silica nanoparticles as drug delivery systems for targeted inhibition of Notch signaling in cancer. Molecular Therapy. 19:1538–1546.

Peuhu E*, Kaunisto A*, Laihia JK, Leino L and Eriksson JE (2010): Molecular targets for the protodynamic action of cis-urocanic acid in human bladder carcinoma cells. BMC Cancer. 10:521.

Rosenholm JM, Peuhu E, Tabe Bate-Eya L, Eriksson JE, Sahlgren C, and Lindén M (2010): Cancer-cell specific induction of apoptosis using mesoporous silica nanoparticles as drug delivery vectors. Small. 6:1234-1241.

Peuhu E, Rivero-Müller A, Stykki H, Torvaldson E, Holmbom T, Eklund P,  Unkila M, Sjöholm R and Eriksson JE (2010): Inhibition of the PI3K/Akt signalling by matairesinol lignan sensitizes prostate cancer cells to TRAIL-induced apoptosis. Oncogene 29, 898–908.

Rosenholm JM*, Peuhu E*, Eriksson JE, Sahlgren C and Lindén M (2009): Targeted Intracellular Delivery of Hydrophobic Agents using Mesoporous Hybrid Silica Nanoparticles as Carrier Systems. Nano Letters 9:3308–3311.

Rosenholm JM, Meinander A*, Peuhu E*, Niemi R, Eriksson JE, Sahlgren C and Lindén M (2009): Targeting of porous hybrid silica nanoparticles to cancer cells. ACS Nano 3:197–206.

Imanishi SY, Kouvonen P, Smått J-H, Heikkilä M, Peuhu E, Mikhailov A, Ritala M, Lindén M, Corthals GL, Eriksson JE (2009): Phosphopeptide enrichment with stable spatial coordination on a titanium dioxide coated glass slide. Rapid Commun Mass Spectrom. 23:3661-3667.

*equal contribution, #co-corresponding